ABSTRACT:

Osteoarthritis (OA) is a chronic, painful, and disabling disease that affects articular cartilage and ligaments, leading to subchondral sclerosis and osteophyte formation, which cause joint deformities. MMP-3 has potential ability to predict the disease on early stage Matrix metalloproteinase (MMPs), a group of ECM-degrading enzymes expressed in joint tissues, are believed to play a crucial role in joint destruction during OA. MMP3 (Stromelysins 1) has been thought to play an essential role in the degradation of the cartilage matrix

200 subject of age between 50 to 80 years, out of which 50 male and 50 female will be normal healthy controls and 50 male and 50 female, were be suffering from knee osteoarthritis patients as Case. Control will be taken from normal healthy male and female individual with equal ratio of same age group.

For the study cases will be newly diagnosed knee osteoarthritic with age group 50 year to 80 year old diagnosed with sign and symptom with radiography.  The mean MMP-3 level in the case group (knee osteoarthritis) was 930.6 ± 357.9, whereas in the control group, it was 370.5 ± 277.8. Authors concluded that MMP-3 is very reliable marker for diagnosis in developing knee osteoarthritic disease.

Keywords: Osteoarthritis, Matrix metalloproteinase, joint disease.