Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin condition that significantly impacts the physical and psychological well-being of affected individuals, particularly adults. This article reviews the epidemiology, pathogenesis, diagnosis, and management of AD, emphasizing the need for effective strategies in primary care. AD commonly starts in early childhood, with a considerable portion of patients experiencing persistent symptoms into adulthood. Diagnosis relies primarily on clinical assessment, with no definitive laboratory tests available. Management strategies encompass both short-term treatment for flares and long-term maintenance therapy, including the use of emollients and topical corticosteroids (TCS). Non-steroidal options like topical calcineurin inhibitors (TCIs) and advanced therapies, such as systemic medications and biologics, are discussed for more severe cases. Patient education is crucial for adherence to treatment regimens, aiming to improve outcomes and reduce healthcare costs. The article also addresses the role of dietary interventions and the importance of recognizing secondary infections in managing AD.