Abstract: COVID-19 has been associated with neuropsychiatric complications, including psychosis. This study presents two cases of new-onset psychosis following COVID-19 vaccination.

The first case is an 18-year-old male who developed irrelevant talk, agitation, and poor self-care within two days of vaccination. The second case involves a 38-year-old bank clerk who experienced hallucinations and paranoia after his second vaccine dose. Both patients had no prior psychiatric history, and routine investigations were unremarkable. Symptoms improved with antipsychotic treatment over a few weeks.

Although psychosis following vaccination is rare, it has been reported with yellow fever, rabies, and pertussis vaccines, possibly due to cytokine-mediated neuroinflammation. While this report does not question vaccine safety, it highlights the need for early identification and monitoring of individuals at risk. Further research is required to understand the mechanisms of vaccine-induced neuropsychiatric symptoms and ensure appropriate management strategies.