This report presents two cases of femoral neuropathy following femoral artery procedures, specifically stent placement and cardiac catheterization. Both patients experienced severe, debilitating pain radiating from the groin to the medial thigh and leg, which was refractory to multiple treatments and consultations with various healthcare professionals. Clinical diagnoses of femoral neuropathy were confirmed through physical examination and, in one case, electromyography and nerve conduction studies (EMG/NCV). Both patients showed significant pain relief after treatment with pregabalin. The first patient, a 65-year-old female, was completely pain-free after two months of therapy, and the second patient, a 78-year-old female, experienced full resolution of pain within a month. This case report highlights the importance of recognizing femoral neuropathic pain as a potential complication following femoral artery interventions. Early diagnosis and appropriate treatment with neuropathic pain medications, such as pregabalin, can significantly improve patient outcomes.