Abstract: Background: Chronic diseases, including cardiovascular disease (CVD), diabetes, and neurodegenerative disorders, are major global health burdens. Oxidative stress and inflammation are central to the pathogenesis of these diseases. Personalized medicine, which tailors interventions based on genetic, environmental, and lifestyle factors, holds promise for more effective management of these diseases. This study explores the role of personalized therapeutic strategies targeting oxidative stress and inflammation in chronic disease management.

Objectives: To investigate the impact of personalized medicine on oxidative stress and inflammation biomarkers in patients with chronic diseases, and to evaluate the effectiveness of tailored interventions in improving clinical outcomes.

Methods: A total of 100 patients with CVD, diabetes, or neurodegenerative diseases were enrolled in this observational study. Participants underwent genetic profiling for common polymorphisms related to oxidative stress and inflammation (e.g., NRF2, TNF-α, IL-6). Lifestyle factors, including diet and exercise, were assessed. Personalized therapeutic interventions, including antioxidant (vitamin C, vitamin E) and anti-inflammatory treatments (curcumin, NSAIDs), were administered based on each participant's biomarker profile and lifestyle factors. Biomarker levels (MDA, 8-iso-PGF2α, oxLDL, TNF-α, IL-6, IL-1β) were measured before and after treatment, and clinical outcomes were assessed.

Results: Personalized medicine led to significant reductions in oxidative stress markers and inflammatory cytokines, with improvements in disease-specific clinical measures such as blood pressure, blood glucose, and cognitive function. The changes were more significant in the personalized treatment group compared to standard care.

Conclusion: Personalized medicine targeting oxidative stress and inflammation offers a promising approach to chronic disease management. Tailoring interventions based on genetic and lifestyle factors can enhance therapeutic efficacy and improve patient outcomes.