Abstract: Oral strip technology, characterized by dissolvable films designed to deliver active pharmaceutical ingredients (APIs) directly through the mucosal tissues in the mouth, presents a novel approach in drug delivery systems. This technology enhances patient compliance due to the ease of administration and the elimination of the need for water, making it especially beneficial for patients with swallowing difficulties. Rapid absorption into the bloodstream facilitates immediate therapeutic effects, bypassing the gastrointestinal tract and reducing the first-pass metabolism, thereby improving the bioavailability of medications. Current advancements focus on incorporating a variety of APIs into these films, exploring innovative materials for improved film properties and dissolution rates. Despite the promising benefits, challenges such as cost efficiency, consumer acceptance, and regulatory hurdles persist. Future directions aim at expanding the range of treatable conditions and enhancing film formulations to include multi-drug combinations for complex therapies.