Abstract: Background: Functional Endoscopic Sinus Surgery represents an advanced surgical technique that has significantly transformed the approach to chronic sinus disorders. Hence; the present study was conducted for assessing and comparing between Dexmedetomidine and Remifentanil for controlled hypotension and recovery under general anaesthesia in Endoscopic Sinus Surgery.

Materials &Methods: A total of 100 patients classified as ASA grade I/II were included in the study. The participants were aged between 20 and 60 years. Each patient underwent a thorough clinical examination, along with basic laboratory tests, chest X-rays, and electrocardiograms. The patients were randomly assigned to one of two groups: Group A, consisting of 50 patients who received dexmedetomidine, and Group B, comprising 50 patients who were administered Remifentanil. Intraoperative assessments and evaluations were performed for one hour postoperatively. The results will be documented and compared between the two groups. Statistical analysis will be conducted using SPSS software, with a significance level set at a p-value of less than 0.05.

Results: Mean age of the patients of group A and group B was 52.3 years and 50.7 years respectively. majority proportion of patients were males. Mean BMI of the patients of group A and group B was 24.8 Kg/m2 and 23.1 Kg/m2.Mean duration of surgery among patients of group A and group B was 83.5 minutes and 81 minutes respectively. Mean time to extubation among patients of group B was shorter in comparison to patients of group A.

Conclusion: Remifentanil and dexmedetomidine both facilitated hypotensive anesthesia and provided optimal intraoperative conditions for endoscopic sinus surgery; however, recovery outcomes were marginally superior with remifentanil compared to dexmedetomidine.